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differential causes management anemia hemolytic bleeding bruising coagulation dic disseminated extravascular hemostasis mds myelodysplasia myelodysplastic oncology petechiae petechial physicalexam rash
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
thrombocytopenic purpura (TTP ... usually IgG) (e.g. lupus ... G6PD deficiency) ... #Hemolytic #Intravascular ... #hematology #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... , Acute hemolysis ... , deficiency anemia ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... with or without platelet ... thrombocytopenia - DIC, TTP ... #Algorithm #workup ... #hematology #testing
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... reflection of intravascular ... hemolysis Platelet ... of Peripheral blood ... #Workup #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... recipients w/ IgA deficiency ... Blood products contain ... #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Blood products contain ... false negatives on testing ... #diagnosis #management ... #hematology #reactions
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Algorithm Pinpoint ... Thrombocytopenia - Abnormal platelet ... Autoimmune Vasculitis (lupus ... Work Up: • ... #dermatology #physicalexam
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... thrombopoietin deficiency ... #Coagulation #diagnosis ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... gingivitis or gingival leukemic ... , disseminated intravascular ... fibrinogen levels, and testing ... #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Hairy Cell Leukemia ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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