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White Blood Cell Maturation Chart

#Pathology #WBC #Maturation #Lineage #Chart #Leukocyte #Myeloid #Myeloblast #Lymphocyte
Lineage #Chart #Leukocyte ... #Myeloid #Myeloblast
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
microscopy • Red cell casts ... glomerular disease • Leukocytes ... • White cell casts ... disease • Granular casts ... • “Muddy brown cast
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... Splenomegaly • ↑ Leukocyte ... Neutrophils • Immature/Myeloblasts ... AML Dx: • ↑ Leukocyte ... differentiated leukocytes
Cerebrospinal Fluid (CSF) Interpretation
Appearance - Opening Pressure - Leukocytes - Differential - Glucose - Protein -
Opening Pressure - Leukocytes ... - Differential ... Interpretation #differential
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
Leukocytosis: The term 'leukocyte ... cells within the myeloblast ... part automated differential ... precursor cells to leukocytes
Causes of Dysuria - Differential Diagnosis Algorithm
Pyuria - Leukocytes on Dipstick/Microscopy
 - Bacteriuria & Hematuria -
Causes of Dysuria - Differential ... Algorithm Pyuria - Leukocytes ... Pyelonephritis - WBC Casts ... No Pyuria - No Leukocytes ... cystitis #Dysuria #Differential
Urinalysis & Urine Sodium 
Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
• Ketones • Leukocyte ... • Urinary casts ... dipstick #nitrite #leucocyte-esterase ... #urine #UNa #casts
Acute Kidney Injury - Differential Diagnosis Framework
PRERENAL:
 - Intrarenal vasoconstriction-hemodynamically mediated
 - Systemic vasodilation
 - Volume
Kidney Injury - Differential ... white blood cell casts ... renal tubular cell casts ... or pigmented casts ... #Injury #AKI #Differential
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... 34t5DgJ #Urinary #Casts ... #Differential #
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... Neutrophil (Normal) Differential ... #Bandemia #differential