10 results
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
- (Reiter’s syndrome ... Systemic Lupus Erythematosus ... (SLE), should have ... other symptoms ... monoarticular #polyarticular
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
of hip (rare), Arthritis ... Demyelinating syndromes ... #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... anti-synthetase syndrome ... , and arthritis ... after 2 years of treatment ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Joint pain • Swan ... arthropathy • 90% joints ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Differential Diagnosis ... constitutional symptoms ... morning • Effusion leukocyte ... #Diagnosis #MSK ... Polyarthritis #Polyarticular
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
bone pain, fever, joint ... Neutrophils • Immature/Myeloblasts ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... Syndrome (SS), ... , Myositis, Mixed ... ANA #patterns #rheumatology ... #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
vesicular eruption - Joints ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... vasculitis, and SLE ... #rheumatology #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
diseases, such as SLE ... ischemia • Skin: Erythematous ... • Progressive symptoms ... Palpable purpura, joint ... #Rheumatology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
sex • Metabolic syndrome ... frequent attacks • Arthritis ... become persistent, polyarticular ... Intracellular (leukocyte ... #rheumatology