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White Blood Cell Maturation Chart

#Pathology #WBC #Maturation #Lineage #Chart #Leukocyte #Myeloid #Myeloblast #Lymphocyte
Lineage #Chart #Leukocyte ... #Myeloid #Myeloblast
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
Leukocytosis: The term 'leukocyte ... cells within the myeloblast ... Leukemoid reaction ... Leukemoid Reaction ... precursor cells to leukocytes
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... Splenomegaly • ↑ Leukocyte ... Neutrophils • Immature/Myeloblasts ... AML Dx: • ↑ Leukocyte ... differentiated leukocytes
Symptoms Distinguishing Groups of Cutaneous Drug Reactions
IgE-mediated reactions:
 • Onset minutes to hours into treatment course
Cutaneous Drug Reactions ... IgE-mediated reactions ... to hours into treatment ... Onset days into treatment ... to weeks into treatment
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Acute transfusion reaction ... recruitment of leucocytes ... hypersensitivity #reactions
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... common immune reaction ... once had another reaction ... - Allergic reaction ... proteins on plts, leukocytes
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Rebound effect from treatment ... syndrome, POEMS • Reaction ... Exercise, Allergic reactions
Drug Treatment of Anaphylaxis and Allergic Reactions
First-Line Therapy 
 - Epinephrine 
 - Oxygen 
 -
Drug Treatment of ... Anaphylaxis and Allergic Reactions
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... common immune reaction ... once had another reaction ... • Allergic reaction ... proteins on plts, leukocytes
Treatment Protocol for Iron Infusion Reactions
Mild reactions
 • Symptoms: back/joint pain, flushing, hypertension, itching,sensation of heat,
Treatment Protocol ... Mild reactions ... tachycardia • Treatment ... wheezing/stridor • Treatment ... #Treatment #Protocol