9 results
diagnosis anemia rheumatology agglutinin algorithm apml causes cbc cold comparison cppd differentiation disease elevatedmcv erythematosus gap globulin gout hemolysis hemolytic
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... ) Differential ... #CBC #hematology ... #pathophysiology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Myelodysplastic Syndromes ... WBCs - Normal ... #elevatedMCV #Differential ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: • Labs: leukocytosis ... initiation • Differential ... diagnosis #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
levels - Usually normal ... from ischemia WBC ... count and differential ... - Shows a mild leukocytosis ... Diagnosis #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Blood smear - RBC ... younger pts) Differential ... passage of red-brown urine ... #hematology #diagnosis
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... Synovial Fluid: • WBCs ... • Metabolic syndrome ... Intracellular (leukocyte ... protein, ESR, leukocytosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... edema, active urine ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... autoimmune hepatitis, PBC ... chain assay • An abnormal ... Gap #ProteinGap #differential ... #diagnosis #hematology
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