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diagnosis differential bag gout hematology management pubs purple bandemia causes cbc clinical comparison complications cppd gitelman hyperuricemia hypokalemia leukemia lower
Metabolic Pathways of Purple Urine Bag Syndrome: Adopted from chart originally published in Purple Urine Bag
Pathways of Purple Urine ... Bag Syndrome: Adopted ... Bag Syndrome: A ... #Pathophysiology ... #Bag #Syndrome
Purple Urine Bag Syndrome Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine Tryptophan → Indoxyl
Purple Urine Bag ... Syndrome Chronic ... E.coli*) + alkaline urine ... #Bag #Syndrome ... #PUBS #pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... Neutrophils • Immature/Myeloblasts ... develop leukostasis syndrome ... AML Dx: • ↑ Leukocyte ... • Tumor lysis syndrome
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... Nephropathy (low urine ... nephropathy (high urine ... #TLS #Pathophysiology
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings - Predisposing Factors: Immunocompromised state, diabetes, elderly, female
urethra), stagnant urine ... systems, or stagnant urine ... Tenderness - Urine ... (+) Nitrites, Leukocyte ... UrinaryTractInfection #LUTI #Pathophysiology
Gout: Pathogenesis and Clinical Findings - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders -
for excretion in urine ... cascade results in leukocyte ... Hyperuricemia #Pathophysiology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... CBC #hematology #pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... Dermatomyositis) AKI - Pathophysiology ... hour with goal urine
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... • Metabolic syndrome ... Intracellular (leukocyte
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... • Gitelman's syndrome ... Hypocalciuria (spot urine ... • Bartter syndrome ... nephrology #management #pathophysiology
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