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diagnosis hematology algorithm workup oncology purpura thrombocytopenia thrombocytosis agglutinin atlas bloodcell bruising classification cold disease elevatedmcv endocrinology extravascular gap globulin
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Diagnosis Platelet ... Reactive: • Anemia ... Myelofibrosis • Chronic Myeloid ... #Diagnosis #causes ... #Platelets #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... lymphoproliferative disorders ... #differential # ... #anemia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... MF) • Chronic myeloid
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Vasculopathy #Purpura #Differential ... #nonpalpable #dermatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... with or without platelet ... Consider RBC membrane disorder ... #Anemia #Differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... - Differential ... changes), high MCV anemia ... #Disorders #Differential ... #Workup #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... lymphoma, Multiple myeloma ... lymphoma, Multiple myeloma ... RBC #Morphology #differential ... #diagnosis #hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Lymphoproliferative Disorders ... Leukemia (CML) - Hemolytic ... Anemia - Others ... endocrinology #causes
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... Platelet count ... and decreased platelet ... anemia Indirect ... WBC count and differential
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Small Bowel Disorder ... Formation • Multiple Myeloma ... #Hematology
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