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diagnosis oncology purpura workup algorithm bruising dermatology disorders leukemia mds myelodysplasia myelodysplastic nonpalpable palpable pediatrics platelet rheumatology secondary syndromes thromboticthrombocytopenicpurpura
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... Myelofibrosis • Chronic Myeloid ... Diagnosis #causes ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Differential #
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... malignancies • Anemia ... MF) • Chronic myeloid ... #hematology #secondary
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... - Differential ... changes), high MCV anemia ... #Differential # ... #Workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... inflammation • Thrombocytopenia ... : - Thrombocytopenia ... - Hemolytic anemia ... Vasculopathy #Purpura #Differential
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... - Fanconi anaemia ... Purpura #Bruising #Causes ... #peds #pediatrics ... #diagnosis #differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (thrombocytopenia ... , or all three myeloid ... IDUS) • Immune Thrombocytopenia ... blood count with differential ... Syndromes #diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... result in severe anemia ... and decreased platelet ... WBC count and differential ... Diagnosis #Workup #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... basophilia, and thrombocytosis ... - infiltrates (anemia ... , thrombocytopenia ... #Leukemia #Hematology
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