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hematology algorithm causes atlas macrocytic rbc agglutinin blood bloodcell chronic classification cold disease elevatedmcv extravascular gap globulin hemolysis hodgkins intravascular
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
CD10 - T-cell ... - Abnormal morphology ... anemia - ... • Lymphoid (CLL ... - B-cell
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Microcytic RBC: ... hemoglobin disorders ... #differential # ... diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Atlas • Microcytic ... cell anemia, Sickle-thalassemia ... #Atlas #key #diagnosis ... #differential #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... other reproducible morphologic ... #Anemia #Differential ... #workup #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... Red cell distribution ... (BM) ablative disorders ... #Workup #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... lymphoproliferative disorders ... G6PD deficiency) ... Hemoglobinopathies (e.g. sickle cell ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... lymphoproliferative disorders ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... specifically: iron deficiency ... , hemolysis, hemorrhage ... Chronic inflammatory disorders ... MF) • Chronic myeloid
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoid malignancy (CLL ... Diagnosis: • hemolytic ... malignancies - B-cell ... malignancies -> CLL ... #anemia #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Diagnosis Algorithm ... • Small Bowel Disorder ... Formation • Multiple Myeloma ... Macrocytosis, Target Cells ... #Causes #Hematology
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