7 results
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
than 1500 and clinical ... Secondary Causes: - Allergic ... #diagnosis #hematology ... #differential # ... management #eosinophils
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Diagnosis Neurologic-Centered ... Ig deposition disease ... #Gammopathy #Clinical ... #Diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... et diutinum Neurologic ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... gammopathy of undetermined ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
skin changes (POEMS ... syndrome) • Solitary ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
injury) • Neurologic ... ) Differential Diagnosis ... : monoclonal TNF-aIpha ... #diagnosis #management ... signs #symptoms #rheumatology
Pathergy Summary Overview

What is pathergy?
Pathergy is an exaggerated skin injury occurring after minor trauma such as
following: • Behcet Disease ... • Chronic myeloid ... interferon-alpha • Atypical eosinophilic ... #allergy #immunology ... #dermatology #skin