8 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... ) - Differential ... Ig deposition disease ... #Differential # ... Diagnosis #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... cancer for which ... No evidence of anemia ... insufficiency, Anemia ... #Monoclonal #Gammopathy
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
tubulopathy • Monoclonal ... gammopathy of renal ... • Hematologic ... #Oncology #Differential ... #Diagnosis #Classification
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... 40 ml/min A - Anemia ... gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Protein/M Component ... • MM • WM • MGUS ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
: • MGUS • Multiple ... myeloma • Waldenstrom ... ovarian tumors, lung cancers ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
younger pts) Differential ... gammopathy of undetermined ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... pancreatitis, protein-losing ... lymphopenia, low PLT • Anemia ... • Cervical cancer