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diagnosis clinical bone bony differential msk oncology tumors honc knee lesions microscopy xray adult algorithm autoinflammatory bonemarrow causes cd138 cilnical
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thrombocytopenia, multiple myeloma ... conditions - multiple myeloma ... (12%) • giant cell ... peripheral blood myeloid ... cells NEJM Review
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Plasma cell leukemia ... other forms of myeloma ... primary plasma cell ... Clinical #Smear #Hematology ... #Pathology
Myeloma: In this BM core, most plasma cells contain cytoplasmic immunoglobulin (Russell bodies). They're difficult to identify
Myeloma: In this ... #Myeloma #CD138 ... RussellBodies #Body ... BoneMarrow #Clinical #Pathology ... #Hematology
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
Non-Malignant • Giant Cell ... tumours • Multiple Myeloma ... Primary #Bone #Bony ... Causes #Oncology #Radiology
Diagram of different types of bone tumors that can occur around the knee on XRay -
years • Multiple Myeloma ... Healed NOF • Giant cell ... Tumors #Diagnosis #Bony ... #Differential #Radiology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... g/dl LLN B - Bony ... marrow plasma cell ... • CML, B and T cell ... MGUS #diagnosis #hematology
Diagram of different types of bone tumors that can occur around the knee on XRay Age <
years: • Multiple Myeloma ... Healed NOF • Giant cell ... Tumors #Lesions #Bony ... Differential #Diagnosis #Radiology
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... clonal plasma cells ... #NEJM #clinical ... #radiology #skull ... raindrop #multiple #myeloma
Perirenal Extramedullary Hematopoiesis - Magnetic resonance imaging of the abdomen, performed without the administration of contrast
erythroid and myeloid ... hematopoiesis #cilnical #Radiology ... #Pathology #Honc ... ExtramedullaryHematopoiesis #Microscopy #NEJM
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
anywhere in the body ... patients with EMD myeloma ... IFE, FLC assay Pathology ... • Multiple myeloma ... Diagnosis #Workup #Hematology
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