10 results
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
whom there are no clinical ... concerning for myeloma ... Biopsy #algorithm #diagnosis ... #management #hematology ... #multiplemyeloma
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... marrow plasma cell ... @AnnKumfer #MultipleMyeloma ... #MGUS #diagnosis ... #hematology #oncology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... (MGUS) - Differential ... Diagnosis Neurologic-Centered ... #Gammopathy #Clinical ... #Diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... younger pts) Differential ... Diagnosis Monoclonal ... , Myeloma • Waldenström ... hemolytic #anemia #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... POEMS (Sclerotic myeloma ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Arthritis) - MSK Radiology ... Differential diagnosis ... • PVNS/Giant Cell ... #Radiology #diagnosis ... #msk #rheumatology
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
The diagnosis was ... clonal plasma cells ... electrophoresis revealed a monoclonal ... #NEJM #clinical ... #radiology #skull
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... (GCA) Giant cell ... Diagnosis = clinical ... very remarkable w/differential ... them, but urgent rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
MGUS • Multiple myeloma ... • Plasma cell ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
plasmacytoma) Clinical ... tissue composed of monoclonal ... IFE, FLC assay Pathology ... • Multiple myeloma ... #Workup #Hematology