31 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... criteria for 1) hematologic ... (12%) • giant cell ... cells NEJM Review
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Plasma cell leukemia ... Aggressive disease ... other forms of myeloma ... #Smear #Hematology ... #Pathology
Acute Graft versus Host disease: vacuolar interface dermatitis w/ lymphoexocytosis, dyskeratotic keratinocytes, notable satellite cell necrosis.
Graft versus Host disease ... notable satellite cell ... #versus #Host #disease ... #Pathology #Microscopy ... #Dermatology #Clinical
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... Management Summary Clinical ... demineralization) • Renal disease ... osteolytic lesions and pathologic ... marrow plasma cells
Urinary Tract Tuberculosis - Contrast-enhanced computed tomography (CT) of the abdomen showed mild dilatation of the
computed tomography (CT ... bacilli (Panel D) #Clinical ... #Radiology #Pathology ... #CT #Urogenital ... AcidFastBacilli #Microscopy #NEJM
Decompression Sickness - The physical examination revealed diffuse violaceous skin mottling over his trunk and arms
and vomiting as well ... #Clinical #Derm ... #EM #Radiology # ... #Pneumatosis #CT ... #NEJM
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... malignancies - B-cell ... , Myeloma • Waldenström ... sensitize red blood cells ... hemolytic #anemia #hematology
Miliary Pattern - Chest Radiology
 • Miliary opacities are scattered, small (1 -4 mm) nodules
 •
Pattern - Chest Radiology ... hematogenous spread of a disease ... Granulomatous: Amyloid ... pulmonary #CXR #clinical ... #CT
Salmonella Aspiration on Microscopy

66 y/o male with history of coronary artery disease presents with abdominal pain.
coronary artery disease ... CT abd/pelvis shows ... international radiology ... Aspiration #Microscopy #clinical ... #pathology #microbiology
Echinococcal Cysts in the Liver- The physical examination revealed hepatomegaly with a palpable hepatic mass. Laboratory
a normal white-cell ... Hydatid disease ... #clinical #NEJM ... liver #hepatic #radiology ... #CT #ultrasonography