10 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... criteria for 1) hematologic ... (12%) • giant cell ... hematopoietic stem cells ... cells NEJM Review
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Plasma cell leukemia ... other forms of myeloma ... primary plasma cell ... Clinical #Smear #Hematology ... #Pathology
Squamous-Cell Carcinoma of the Tongue - Intraoral examination revealed a well-circumscribed superficial ulcer, with a homogeneous
Squamous-Cell Carcinoma ... invasive squamous-cell ... B) #Clinical #Pathology ... #Honc #SCCa #SCC ... Squamous #Microscopy #NEJM
Glucagonoma-Associated Rash - The rash involved the arms, genitals, and buttocks and had progressed to the
- The rash involved ... tissue revealed a well-circumscribed ... D) #Clinical #HONC ... #Derm #Pathology ... Microscopy #CT #NEJM
Myeloma: In this BM core, most plasma cells contain cytoplasmic immunoglobulin (Russell bodies).

They're difficult to identify
Myeloma: In this ... core, most plasma cells ... #Myeloma #CD138 ... BoneMarrow #Clinical #Pathology ... #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
breast CA, small cell ... lymphoma, melanoma, myeloma ... fibrosis, Sickle cell ... disease: > 2 • NASH ... diagnosis #algorithm #hepatology
Perirenal Extramedullary Hematopoiesis - Magnetic resonance imaging of the abdomen, performed without the administration of contrast
erythroid and myeloid ... cilnical #Radiology #Pathology ... #Honc #MRI #PerirenalExtramedullaryHematopoiesis ... ExtramedullaryHematopoiesis #Microscopy #NEJM
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
as neoplasm or amyloid ... disease: > 2 • NASH ... intestines, White blood cells ... #differential #Hepatology
Common Dermatological Conditions - Distribution and Morphology
 • Acne vulgaris - Face, upper back, chest -
scale • Basal cell ... skin • Squamous cell ... blood-filled papules • Keloid ... ; pruritis #dermatology ... #rash #differential
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
Solitary Cell Plasmacytoma ... patients with EMD myeloma ... IFE, FLC assay Pathology ... • Multiple myeloma ... Diagnosis #Workup #Hematology