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differential management monoclonal agglutinin aplastic autoinflammatory blood cancer causes disorders e1 elevatedmcv gammopathies gap globulin hemolytic leukemia macrocytic macrocytosis markers
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... syndrome (MDS) ... syndrome (MDS) ... cells NEJM Review ... Autoinflammatory #Somatic #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - ... Diagnosis and Management ... Summary myelo ... #Syndrome #MDS ... #treatment #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Disorders - Markers and ... Disorders - Myelodysplastic ... Pelger-Huet, Macrocytic anemia ... - Amy Chung, MD ... Blood #Disorders #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... diseases, CML, ... #diagnosis #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... three myeloid hematopoiesis ... Myeloproliferative Disease ... #Syndromes #diagnosis ... #hematology #oncology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Formation • Multiple Myeloma ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... • Rule out B12 and ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... anemia • Cold ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Anticonvulsants - Gold ... • Hypocellular myelodysplastic ... syndrome (MDS) ... #oncology #hematology ... #diagnosis #management
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