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diagnosis management vasculitis classification dermatology comparison hodgkins leukemia lupus lymphoma monoclonal myelodysplastic skin sle agglutinin ana anemia antibodies antinuclear approach
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... thromboembolic disease ... • giant cell arteritis ... cells NEJM Review ... Autoinflammatory #Somatic #rheumatology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
• Myeloid hemopathy ... appearing during the disease ... #differential # ... diagnosis #dermatology ... #oncology #clinical
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Involving the Skin - Differential ... Vasculitis: • Behcet Disease ... • Cogan syndrome ... #rheumatology # ... differential #diagnosis
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... nemaline myopathy Cutaneous-centered ... Ig deposition disease ... #Diagnosis #hematology ... #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... vasculitis) • Cutaneous ... (Clinical Dx). ... ) Differential Diagnosis ... signs #symptoms #rheumatology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
Symptoms of Joint Disease ... Enthesitis: • Site of pathology ... Joint #Pain #MSK #rheumatology ... #approach #workup ... #differential #
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... : GI, neuro, cutaneous ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Clinical Features ... Erythematosus #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... gangrenosum • Cutaneous ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... SLE), Sjogren's Syndrome ... , Sjögren Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
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