238 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
onset of muscle symptoms ... , hypothyroid-induced ... syndrome (GBS), ... antisynthetase syndrome ... Lambert-Eaton myasthenic syndrome
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Differential diagnosis of myopathy ... Fibromyalgia #Hypothyroid ... myopathy #Muscle ... Statin-induced myopathy ... Cocaine-induced myopathy
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Hypothyroidism – symptoms ... Symptoms: Tiredness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy ... reflexes, Anaemia #Hypothyroid
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... Symmetric, proximal myopathy ... Rhabdomyolysis (rare) #Hypothyroid ... #Myopathy #pathophysiology ... #signs #symptoms
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... varied clinical symptoms ... There are several symptoms ... Myopathy due to ... endocrinology #hypothyroid
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
Myelopathy - Injury ... cord - Signs and Symptoms ... early signs) #Myelopathy ... diagnosis #signs #symptoms
Causes of Back Pain - Differential Diagnosis Algorithm
Always assess for red flags. If no red flags,
constitutional symptoms ... Unresolved Radicular Symptoms ... • Cauda Equina Syndrome ... Spondyloarthropathies • Myelopathic
Causes of Generalized Edema - Differential Diagnosis Algorithm
Overfill (Increased renal sodium retention, Urine Na > 40meq/L)
• Nephrotic Syndrome ... • Myxedema (Hypothyroid ... • Nephrotic syndrome ... Respiratory Distress Syndrome
Ramsay Hunt Syndrome - Herpes Zoster Oticus 
Triad:
1. Ipsilateral facial paralysis 
2. Ear pain 
3. Vesicles
Ramsay Hunt Syndrome ... Guillain-Barré syndrome ... • Stroke syndromes ... #RamsayHunt #Syndrome ... Oticus #Diagnosis #Symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... less systemic symptoms ... anti-synthetase syndrome ... and anti-HMGCR myopathy