73 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... level of muscle weakness ... anti-synthetase syndrome ... and anti-HMGCR myopathy
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Critical Illness Myopathy ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... - Autoimmune
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Causes of Proximal ... Muscle Weakness ... Mimic Inflammatory Myopathy ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... antisynthetase syndrome ... (SAMS-CI) • EMG
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Weakness • Spinal ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Causes of Peripheral ... Weakness without ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... Diagnosis #Algorithm #Causes
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm
With Sensory Changes:
Causes of Peripheral ... Weakness - With ... • No Objective Weakness ... Oculomotor • Myopathy ... Diagnosis #Algorithm #Causes
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Myopathy: ... mediated necrotizing myopathy ... • Autoimmune: ... electromyographic (EMG
Hypercalcemia - EKG Findings
Causes of Hypercalcemia 
• Malignancy 
• Milk-alkali syndrome 
• Vitamin D toxicity 
•
Findings Causes ... • Milk-alkali syndrome ... Hypercalcemia #EKG ... #Differential #Causes ... #Diagnosis #Cardiology
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Any inflammatory myopathy ... features of another autoimmune ... antisynthetase syndrome ... Inflammatory myopathy ... #dermatology #Myopathy