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diagnosis rhabdomyolysis causes differential management nephrology ck treatment acute acutemyocardialinfarction aki algorithm alkphos ami antinxp2 antinxp2dm astalt bilirubin biomarkers cardiac
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Myoglobin levels ... Myoglobin has a ... metabolism makes serum myoglobin ... creatinekinase #CK #myoglobin
Acute Myocardial Infarction - Biomarker time course #Diagnosis #Cardiology #AcuteMyocardialInfarction #AMI #Biomarkers #Enzymes #Troponins #CKMB #Myoglobin
Troponins #CKMB #Myoglobin
ACUTE COMPARTMENT SYNDROME The definitive surgical therapy for compartment syndrome is emergent fasciotomy (compartment release), with
Urinalysis * Urine myoglobin ... compartmentsyndrome #myoglobin
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
• Myoglobin half-life ... metabolism makes myoglobin
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
with no RBC’s, + myoglobin ... Direct myoglobin
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Rhabdo-myolysis: CK, myoglobin
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
(80% Hgb, rest myoglobin
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Direct myoglobin
Rhabdomyolysis - Differential Diagnosis Framework Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation.
proteins (CK, myoglobin
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Aldolase • Myoglobin
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