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diagnosis rhabdomyolysis causes differential management nephrology ck treatment acute acutemyocardialinfarction aki algorithm alkphos ami antinxp2 astalt bilirubin biomarkers cardiac cardiology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Aldolase • Myoglobin ... three days #AntiNXP2DM ... #AntiNXP2 #Dermatomyositis
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
• Myoglobin half-life ... metabolism makes myoglobin
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Myoglobin levels ... Myoglobin has a ... metabolism makes serum myoglobin ... creatinekinase #CK #myoglobin
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Rhabdo-myolysis: CK, myoglobin
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
with no RBC’s, + myoglobin ... Direct myoglobin
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
(80% Hgb, rest myoglobin
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Direct myoglobin
Acute Myocardial Infarction - Biomarker time course #Diagnosis #Cardiology #AcuteMyocardialInfarction #AMI #Biomarkers #Enzymes #Troponins #CKMB #Myoglobin
Troponins #CKMB #Myoglobin
ACUTE COMPARTMENT SYNDROME The definitive surgical therapy for compartment syndrome is emergent fasciotomy (compartment release), with
Urinalysis * Urine myoglobin ... compartmentsyndrome #myoglobin
Rhabdomyolysis - Differential Diagnosis Framework Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation.
proteins (CK, myoglobin
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