244 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
(80% Hgb, rest myoglobin ... Laboratory #Metabolism #ASTALT
RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Myoglobin half-life ... metabolism makes myoglobin
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Myoglobin levels ... Myoglobin has a ... metabolism makes serum myoglobin ... creatinekinase #CK #myoglobin
The SALT Mass Casualty Triage Approach
 - SALT stands for “Sort, Assess, Lifesaving interventions, and Treatment
The SALT Mass Casualty ... Triage Approach - SALT ... alternative to START ... Management #Disaster #SALT
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
By AST:ALT Ratio ... : AST:ALT = ... Ischemia, CHF AST ... Hepatitis AST
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Rhabdo-myolysis: CK, myoglobin
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
with no RBC’s, + myoglobin ... Direct myoglobin
Insulin Comparison Chart

Insulin Types - Onset (hours) - Peak Glycemic Effect (hours) - Duration (hours)
 •
Lispro (Humalog), Aspart ... Combination Insulins: Aspart ... + Degludec, Aspart ... Protamine + Aspart
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Direct myoglobin
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
maintain long-term Salt ... tablets: • Start ... and frequency of salt