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diagnosis differential hepatology management algorithm hematology causes liver treatment workup gastroenterology urine laboratory nephrology pathophysiology rhabdomyolysis anemia biliary hemolytic hepatitis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... (80% Hgb, rest myoglobin ... transports conjugated bilirubin ... ASTALT #AlkPhos #Bilirubin
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
, haptoglobin, bilirubin ... Rhabdo-myolysis: CK, myoglobin
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... • Conjugated Bilirubin ... • Unconjugated Bilirubin ... LouLectures #Bilirubin
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... Conjugation → Conjugated Bilirubin ... and "indirect" bilirubin
Approach to Neonatal Jaundice Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
(1) increased bilirubin ... , (2) impaired bilirubin ... or (3) impaired bilirubin
Bilirubin Crystals on Urine Microscopy Dr. Telma Lemos @TELMALEMOS10 #Bilirubin #Crystals #crystalluria #Urine #Microscopy #trichomoniasis #clinical
Bilirubin Crystals ... TELMALEMOS10 #Bilirubin
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 RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
• Myoglobin half-life ... metabolism makes myoglobin
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
birth with serum bilirubin ... associated with bilirubin ... days of life • Bilirubin ... in conjugated bilirubin ... in conjugated bilirubin
Jaundice Differential Diagnosis: A short guide By Dr. Khudhur Mohammed @khudhur_moh #jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
hyperbilirubinemia #bilirubin
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
predominantly indirect bilirubin ... • Increased bilirubin ... ) • Impaired bilirubin ... predominantly direct bilirubin ... Faulty excretion of bilirubin
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