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Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
with no RBC’s, + myoglobin ... Direct myoglobin ... oxidative injury Treatment ... Treatment of underlying ... Management #causes #treatment
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Direct myoglobin ... oxidative iniury Treatment ... Summary #causes #treatment
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
• Myoglobin half-life ... metabolism makes myoglobin
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Myoglobin levels ... Myoglobin has a ... metabolism makes serum myoglobin ... creatinekinase #CK #myoglobin
Pharmacologic Treatments of Chronic Hypertension in Pregnancy Central alpha-agonists - Methyldopa - Clonidine Combined alpha- and beta-blocker -
Pharmacologic Treatments ... Pregnancy #Management #Treatment
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Rhabdo-myolysis: CK, myoglobin
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
(80% Hgb, rest myoglobin
Algorithm for the Treatment of Uremic Pruritus Nonpharmacologic Treatments: • Daily topical emollient • Avoidance of extremes
Algorithm for the Treatment ... Nonpharmacologic Treatments ... Pharmacologic Treatments ... max 75 mg daily Treatments ... itching #Algorithm #Treatment
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment ... the first-line treatments
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 This is an oversimplified, hypothetical model to think about time from symptom onset and stages of
determine what treatments ... clinical #management #treatment
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