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Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Mitochondrial myopathy ... , Polymyositis/dermatomyositis ... differential #diagnosis #neurology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
• Congenital Myopathy ... Statin Toxicity • Dermatomyositis ... Peripheral #Weakness #Neurology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
proximal weakness Myopathy ... • Metabolic myopathies ... aminotransferases • Serology ... Muscle Biopsy: Dermatomyositis ... Differential #Diagnosis #neurology
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myositis and Myopathies ... #Inflammatory #myopathies ... #Dermatomyositis ... #Hypothyroid myopathy ... Statin-induced myopathy
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... - Dermatomyositis ... Immune-Mediated Necrotizing Myopathy ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... or peripheral neurologic ... • Metabolic myopathies ... Mitochondrial myopathy ... differential #causes #neurology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... load Drug-induced myopathy ... 5-15% of lupus myopathy ... #myopathy #differential
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Metabolic Myopathies ... - Inflammatory myopathy ... : dermatomyositis ... polymyositis, necrotizing myopathy
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... polymyositis, dermatomyositis ... → Inflammatory myopathies ... Statin-induced myopathy ... - Necrotizing myopathy
Dermatomyositis A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
Dermatomyositis ... This is a case of dermatomyositis ... usually indicates myopathy ... AndreMansoor #Dermatomyositis
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