91 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
#ESR #CK #Differential ... diagnosis of myopathy ... #Dermatomyositis ... #Hypothyroid myopathy ... Statin-induced myopathy
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... - Dermatomyositis ... Immune-Mediated Necrotizing Myopathy ... #Idiopathic #Myopathy ... #Rheumatology #Differential
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Anti-Jo, +Anti-Mi2 Dermatomyositis ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... #myopathy #differential
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Inflammatory myopathy ... : dermatomyositis ... polymyositis, necrotizing myopathy ... #Elevated #CK #differential
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Sensory Changes - Differential ... • Congenital Myopathy ... Statin Toxicity • Dermatomyositis ... Weakness #Neurology #Differential
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Mitochondrial myopathy ... , Polymyositis/dermatomyositis ... Weakness #Causes #differential
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... NECROTIZING AUTOIMMUNE MYOPATHY ... syndrome • If myopathy ... ANTI-MITOCHONDRIAL MYOPATHY ... Autoimmune #Myositis #Myopathy
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... proximal weakness Myopathy ... mediated necrotizing myopathy ... Muscle Biopsy: Dermatomyositis ... #Weakness #Differential
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... • Metabolic myopathies ... Mitochondrial myopathy ... MuscleWeakness #Myopathy ... mimics #diagnosis #differential
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... polymyositis, dermatomyositis ... Statin-induced myopathy ... - Necrotizing myopathy