65 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
#Inflammatory ... #myopathies #Dermatomyositis ... #Hypothyroid myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory ... Dermatomyositis ... Immune-Mediated Necrotizing Myopathy ... TerrierBen #Inflammatory ... #Myopathy #Comparison
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
myopathy, rhabdomyolysis ... , toxic myopathy ... polymyositis, dermatomyositis ... Statin-induced myopathy ... - Necrotizing myopathy
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Metabolic Myopathies ... toxoplasmosis - Inflammatory ... myopathy: dermatomyositis ... polymyositis, necrotizing myopathy
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
Systemic Findings in Dermatomyositis ... - Symmetric, inflammatory ... myopathy (Triceps ... Arrhythmias - Inflammatory ... Findings #Signs #Dermatomyositis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
spinal cord • Inflammatory ... proximal weakness Myopathy ... : • Inflammatory ... mediated necrotizing myopathy ... Muscle Biopsy: Dermatomyositis
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Diagnosis Framework Inflammatory ... NECROTIZING AUTOIMMUNE MYOPATHY ... syndrome • If myopathy ... ANTI-MITOCHONDRIAL MYOPATHY ... Autoimmune #Myositis #Myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Anti-Jo, +Anti-Mi2 Dermatomyositis ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... #myopathy #differential
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
That May Mimic Inflammatory ... Myopathy • Central ... • Metabolic myopathies ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Idiopathic Inflammatory ... Myopathies (IIM's ... myopathy that occurs ... myopathy affecting ... #dermatology #Myopathy