25 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... such as • Statin-induced ... myopathy (SAMS) ... Atorvastatin Diagnosis ... #diagnosis #management
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... , holster sign, ... anti-synthetase syndrome ... and anti-HMGCR myopathy ... after 2 years of treatment
Acute Coronary Syndrome - Diagnostic Likelihood Ratios for Symptoms and Physical Examination. 

Source:  Does This
Acute Coronary Syndrome ... - Diagnostic Likelihood ... #EBM #Diagnosis ... #Cardiology #ACS ... AcuteCoronarySyndrome #Symptoms #Signs
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... MSAs #clinical #diagnosis ... #rheumatology #table
Cardiorenal Syndrome (CRS) Types
 • Type 1 - Acute CRS: Alteration of renal perfusion is the
Cardiorenal Syndrome ... Type 3 - Acute RCS ... Hypertension, CKD induced myopathy ... #Cardiorenal #Syndrome ... #CRS #Types #cardiology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Motor Nerves: ALS ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy ... #differential #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... proximal weakness Myopathy ... mediated necrotizing myopathy ... #Differential #Diagnosis
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... , Deafness Signs ... Carpal timel syndrome ... hypertrophy, Proximal myopathy ... #Symptoms #Diagnosis
Effects of Strokes by Location - Anterior vs Posterior Localization

Anterior Circulation 
 - MCA 
 -
- MCA - ACA ... Artery #Strokes #Syndromes ... Territory #Symptoms #Signs ... Effects #Neurology #Diagnosis ... #Table #Territories
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: - Neuro: AMS ... have fever - ACS ... WBC >100k, + lab signs ... organ damage • Treatment ... #TLS #diagnosis