13 results
differential neurology rheumatology causes autoimmune management ophthalmology rhabdomyolysis treatment algorithm antibodies ck cord creatine dermatology diplopia disorders elevated generalized idiopathic
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #IIMs #diagnosis ... #dermatology #Myopathy
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... proximal myalgia and weakness ... symmetric muscle weakness ... • Myalgia • Myositis ... inclusion body myositis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Necrotizing myopathy ... level of muscle weakness ... anti-synthetase syndrome ... /full triad at diagnosis ... and anti-HMGCR myopathy
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Illness Myopathy ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... Inclusion body myositis ... #differential #diagnosis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Diagnosis Framework ... • Acute stroke syndromes ... Myopathy: ... mediated necrotizing myopathy ... #Differential #Diagnosis
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Motor Nerves: ALS ... heavy metals), Critical ... Mitochondrial myopathy ... #differential #diagnosis
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness ... I am weak": • Myopathy ... Rhabdomyolysis, Critical ... Polyneuropathy, ALS ... Inflammatory/Rheum: Myositis
Important Causes of Diplopia TIER 1-CRITICAL Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn TIER 2-EMERGENT: Vertebral dissection, Myasthenia gravis,
Diplopia TIER 1-CRITICAL ... , Orbital apex syndrome ... sclerosis, Thyroid myopathy ... neuropathy, Orbital myositis ... #differential #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... NECROTIZING AUTOIMMUNE MYOPATHY ... • If myopathy ... ANTI-MITOCHONDRIAL MYOPATHY ... #Myopathy #rheumatology
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