29 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myositis and Myopathies ... #Differential diagnosis ... Inflammatory #myopathies ... Dermatomyositis #muscle weakness ... #Drug-induced myopathies
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... 5-15% of lupus myopathy ... BostonChiefs #Myositis #Myopathies ... #myopathy #differential ... #diagnosis #comparison
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Idiopathic Inflammatory Myopathies ... Any inflammatory myopathy ... Inflammatory myopathy ... #Inflammatory #Myopathies ... #dermatology #Myopathy
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Proximal Muscle Weakness ... Mimic Inflammatory Myopathy ... • Metabolic myopathies ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Metabolic Myopathies ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... #differential #diagnosis
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... → Inflammatory myopathies ... Atorvastatin Diagnosis ... #diagnosis #management
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Diagnosis Framework ... Myopathy: ... mediated necrotizing myopathy ... • Metabolic myopathies ... certain drug-induced myopathies
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Mitochondrial myopathy ... #differential #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... anti-synthetase syndrome ... /full triad at diagnosis ... and anti-HMGCR myopathy