17 results
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... Inclusion Body Myositis ... #Idiopathic #Myopathy ... #Comparison #Managment
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... • Inflammatory myopathy ... inclusion body myositis ... Statin-induced myopathy ... #diagnosis #management
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... anti-synthetase syndrome ... triad of ILD, myositis ... and anti-HMGCR myopathy
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
• Overlap Myositis ... Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #dermatology #Myopathy
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... Inclusion Body Myositis ... MithuRheum #Myositis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... proximal weakness Myopathy ... mediated necrotizing myopathy
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
, Orbital apex syndrome ... Miller-Fisher syndrome ... sclerosis, Thyroid myopathy ... neuropathy, Orbital myositis
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Tetanus, Transverse Myelitis ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy
Cardiorenal Syndrome (CRS) Types
 • Type 1 - Acute CRS: Alteration of renal perfusion is the
Cardiorenal Syndrome ... Hypertension, CKD induced myopathy ... #Cardiorenal #Syndrome ... #CRS #Types #cardiology
2 Percent MACE Image - After calculating the risk for acute coronary syndrome, select the corresponding
acute coronary syndrome ... #Management #PatientInfo ... #Cardiology #ChestPain