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diagnosis differential neurology algorithm causes clinical rheumatology treatment chestpain radiology msk myopathies weakness decisionaid fracture hypothyroid inflammatory lowrisk orthopedics patientinfo
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myositis and Myopathies ... Differential diagnosis of myopathy ... #Hypothyroid myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... Inclusion Body Myositis ... #Idiopathic #Myopathy ... #Comparison #Managment
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... #Myopathies #myopathy
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... • Inflammatory myopathy ... inclusion body myositis ... Statin-induced myopathy ... #diagnosis #management
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... anti-synthetase syndrome ... triad of ILD, myositis ... and anti-HMGCR myopathy
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
• Overlap Myositis ... Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #dermatology #Myopathy
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... Inclusion Body Myositis ... MithuRheum #Myositis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... proximal weakness Myopathy ... mediated necrotizing myopathy
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Metabolic Myopathies ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... Inclusion body myositis
Important Causes of Diplopia TIER 1-CRITICAL Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn TIER 2-EMERGENT: Vertebral dissection, Myasthenia gravis,
, Orbital apex syndrome ... Miller-Fisher syndrome ... sclerosis, Thyroid myopathy ... neuropathy, Orbital myositis
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