76 results
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... #Idiopathic #Myopathy ... Comparison #Managment #algorithm
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... Statin-induced myopathy ... - Necrotizing myopathy ... fibers Risk of myopathy
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... less systemic symptoms ... anti-synthetase syndrome ... and anti-HMGCR myopathy
Ashkenazi Jewish Genetic Screening Algorithm
 • Bloom syndrome
 • Canavan disease
 • Familial dysautonomia
 • Fanconi
Genetic Screening Algorithm ... • Bloom syndrome ... 1A • Joubert syndrome ... NEB-related nemaline myopathy ... Genetic #Screening #Algorithm
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... varied clinical symptoms ... There are several symptoms ... and scaly skin, myopathy ... Myopathy due to
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Idiopathic Inflammatory Myopathies ... Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #dermatology #Myopathy
Abdominal Distention - Differential Diagnostic Algorithm
Ascites
Bowel Dilatation
Other Causes
Mechanical Obstruction
 • Adhesions 60%
 • Volvulus 3%
 •
Differential Diagnostic Algorithm ... Intestinal Ogilvie's Syndrome ... • Ischemic Myopathic ... Scleroderma • Familial Myopathy ... Differential #Diagnosis #Algorithm
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... Symmetric, proximal myopathy ... #Hypothyroid #Myopathy ... pathophysiology #signs #symptoms
Symptoms of Hypophosphatemia
 • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue
 • Hematologic:
Symptoms of Hypophosphatemia ... MSK: Proximal myopathy ... Hypophosphatemia #Phosphate #Symptoms
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Hypothyroidism – symptoms ... Symptoms: Tiredness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy ... Features #Signs #Symptoms