998 results
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #IIMs #diagnosis ... #dermatology #Myopathy
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... Statin-induced myopathy ... - Necrotizing myopathy ... Atorvastatin Diagnosis ... #diagnosis #management
Abdominal Distention - Differential Diagnostic Algorithm
Ascites
Bowel Dilatation
Other Causes
Mechanical Obstruction
 • Adhesions 60%
 • Volvulus 3%
 •
- Differential Diagnostic ... Intestinal Ogilvie's Syndrome ... • Ischemic Myopathic ... Scleroderma • Familial Myopathy ... #Differential #Diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... anti-synthetase syndrome ... /full triad at diagnosis ... and anti-HMGCR myopathy ... Autoimmune #Myositis #diagnosis
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
, Orbital apex syndrome ... Miller-Fisher syndrome ... sclerosis, Thyroid myopathy ... #differential #diagnosis
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... MSAs #clinical #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... • Acute stroke syndromes ... proximal weakness Myopathy ... mediated necrotizing myopathy ... #Differential #Diagnosis
Ashkenazi Jewish Genetic Screening Algorithm
 • Bloom syndrome
 • Canavan disease
 • Familial dysautonomia
 • Fanconi
Algorithm • Bloom syndrome ... 1A • Joubert syndrome ... type 1B • Usher syndrome ... NEB-related nemaline myopathy ... Screening #Algorithm #diagnosis
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy ... #differential #diagnosis
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
- Differential Diagnosis ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... #Differential #Diagnosis