41 results
diagnosis differential causes algorithm clinical weakness management physicalexam myositis signs video inflammatory lupus myopathies symptoms systemic treatment arthritis autoimmune comparison
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... #Idiopathic #Myopathy ... Managment #algorithm #Rheumatology
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... or peripheral neurologic ... Mitochondrial myopathy ... MuscleWeakness #Myopathy ... differential #causes #neurology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
rimmed vacuoles HIV myopathy ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... #myopathy #differential
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... Statin-induced myopathy ... - Necrotizing myopathy ... fibers Risk of myopathy
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... IIMs #diagnosis #rheumatology ... #dermatology #Myopathy
Neurological Patterns of Weakness • Hemispheric lesion • Brainstem lesion • Spinal cord lesion • Polyneuropathy
Polyneuropathy • Myopathy ... #Neurology #Patterns
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... anti-synthetase syndrome ... and anti-HMGCR myopathy ... Myositis #diagnosis #rheumatology
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... clinical #diagnosis #rheumatology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... proximal weakness Myopathy ... mediated necrotizing myopathy ... Differential #Diagnosis #neurology
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy ... differential #diagnosis #neurology
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