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diagnosis symptoms signs differential management endocrinology cardiology pharmacology nephrology syndrome causes algorithm neurology ophthalmology complications infectiousdiseases msk lifecycle cdc hematology
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
Hypothyroid Myopathy ... hypothyroidism Pathophysiology ... Symmetric, proximal myopathy ... #Hypothyroid #Myopathy ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
femoral heads • Myopathy ... Complications #pathophysiology
Daptomycin - Pharmacology Mechanism of Action - Cyclic lipopeptide Antimicrobial Spectrum - Gram Positive Pharmacokinetics (Penetration) Dose: • SSTI:
Adverse Effects: Myopathy ... #Pharmacology #pathophysiology
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myositis and Myopathies ... #Inflammatory #myopathies ... #Hypothyroid myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
stroke, Metabolic myopathies ... Dermatomyositis) AKI - Pathophysiology
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... #myopathy #differential
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... • Metabolic myopathies ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Pathogenesis of Select Causes of Constipation in Adults and in Elderly • Mechanical (ex. Bowel Obstruction,
neuromuscular disorders, myopathy ... #constipation #pathophysiology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... → Inflammatory myopathies ... Statin-induced myopathy ... - Necrotizing myopathy
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