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management diagnosis differential neurology gastroenterology causes hematology nephrology pulmonary rheumatology cardiology endocrinology oncology guidelines disease hepatology pharmacology syndrome hyperkalemia ibd
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myositis and Myopathies ... #Inflammatory #myopathies ... Dermatomyositis #muscle weakness ... #Hypothyroid myopathy ... Statin-induced myopathy
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
symmetric muscle weakness ... symmetric muscle weakness ... Fever, No muscle weakness ... asymmetric muscle weakness ... Proximal muscle weakness
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy ... Comparison #Managment #algorithm
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Proximal Muscle Weakness ... Mimic Inflammatory Myopathy ... • Metabolic myopathies ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... any time during treatment ... symmetric muscle weakness ... after DC Statin Treatment ... diagnosis #management #treatment
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Elevation (Pain > Weakness ... Critical Illness Myopathy ... Chronic Causes (Weakness ... PROXIMAL MUSCLE WEAKNESS ... - Inflammatory myopathy
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm With Sensory Changes:
of Peripheral Weakness ... Differential Diagnosis Algorithm ... • No Objective Weakness ... Oculomotor • Myopathy ... Differential #Diagnosis #Algorithm
Neurological Patterns of Weakness • Hemispheric lesion • Brainstem lesion • Spinal cord lesion • Polyneuropathy
Neurological Patterns of Weakness ... Polyneuropathy • Myopathy ... Neurology #Patterns #Weakness
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... and anti-HMGCR myopathy ... have significant weakness ... after 2 years of treatment
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Myopathy: ... mediated necrotizing myopathy ... • Metabolic myopathies ... certain drug-induced myopathies
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