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diagnosis management erythematosus lupus sle systemic anca antibody antineutrophil antinxp2 antinxp2dm criteria dermatology dermatomyositis differential disease diseases eularacr igg4 phenotypes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... scleroderma) - Anti-Scl ... Jcortesizaguirr #ANA ... #Antinuclear #Antibody ... #rheumatology #
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... hemolysis • Renal ... low C4, Low C3 and ... Highly specific antibodies ... Erythematosus #diagnosis #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
aorta • Head and ... pancreas, biliary, renal ... autoantibodies (antinuclear ... antibodies, rheumatoid ... workup #treatment #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Non-autoimmune rheumatologic ... La, anti-Jo-1, SCL ... -70, RNP antibodies ... anticardiolipin antibodies
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... examination Labs: • Antibodies ... ab • RF • Antinuclear ... antibodies ≥ 1: ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
renal abnormalities ... LFT • ESR • ANA ... ) pattern: antibodies ... differential #diagnosis #rheumatology ... #classification
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
severe weakness, and ... • Antibodies targeting ... dorsal part of the MCP ... • Clear cell renal ... diagnosis #management #rheumatology
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