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diagnosis management sle ana anca antibodies antibody antineutrophil antinuclear antinxp2dm dermatology dermatomyositis differential diseases erythematosus hcq hematology hydroxychloroquine levels measurement
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... probably < 1500ng/mL ... Special cases (e.g. renal ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... scleroderma) - Anti-Scl ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... antibodies #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... La, anti-Jo-1, SCL ... Erythematosus #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & MBL ... to cold IgG • Lupus ... vascular beds-renal ... , retinal, DVT, ... Paraproteinemias #Hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
dorsal part of the MCP ... • Clear cell renal ... three days #AntiNXP2DM ... #AntiNXP2 #Dermatomyositis ... diagnosis #management #rheumatology
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