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diagnosis hematology oncology differential gammopathy significance behcet clinical complications disease gammopathies gap globulin management multiplemyeloma paraproteinemias protein proteingap signs symptoms
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Cryoglobulinemia Renal-centered ... (ie "MGRS"): ... #Significance #MGUS ... Differential #Diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... (HCV) • CLL & MBL ... Amyloidosis and monoclonal ... , retinal, DVT, ... Paraproteinemias #Hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma and Monoclonal ... dL the ULN R - Renal ... /dL or CC < 40 ml ... #Gammopathies #MGUS ... #diagnosis #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... hyperCalcemia, Renal ... #Significance #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Complications of Monoclonal ... Significance (MGUS ... ; vaccinations Renal ... high-risk situations #MGUS ... Complications #diagnosis #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
disease (panuveitis, retinal ... involvement (uveitis or retinal ... Ocular: Giant retinal ... refractory disease : monoclonal ... signs #symptoms #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
it represents a monoclonal ... Causes of Monoclonal ... Gammopathy Include: • MGUS ... endocrinopathy, monoclonal ... cancers, HCC, renal
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