5795 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... MithuRheum #Myositis ... MSAs #clinical #diagnosis
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myositis and Myopathies ... #Differential diagnosis ... Inclusion body myositis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... triad of ILD, myositis ... /full triad at diagnosis ... #Autoimmune #Myositis ... #diagnosis #rheumatology
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis ... BostonChiefs #Myositis ... #differential #diagnosis
Differential Diagnosis of Necrotizing Fasciitis: 

Cellulitis, 
Superficial abscess, 
Deep vein thrombosis 
(see phlegmasia cerulea dolerans), 
Compartment
Differential Diagnosis ... Necrotizing myositis ... #Differential #Diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Inclusion body myositis ... anti-RNP - (Myositis ... inclusion body myositis ... #Differential #Diagnosis
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
involve DIP • Myositis ... #Scleroderma #diagnosis
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Associated Features: Diagnosis ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis ... over years, often diagnosed ... #differential #diagnosis
Causes of Rhabdomyolysis - Differential Diagnosis
 • Drugs & Toxins (Statins, alcohol, cocaine)
 • Direct Muscle
- Differential Diagnosis ... Muscle Disease (myositis ... #Differential #Diagnosis
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
neuropathy, Orbital myositis ... #differential #diagnosis