51 results
Small Vessel Vasculitides
 • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... and C viruses. systemic ... lupus erythematosus ... and Sjogren's syndrome ... • IgA vasculitis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... - Budd Chiari Syndrome ... distension #Systemic ... #Lupus #Erythematosus
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
central nervous system ... Churg-Strauss syndrome ... disease - systemic ... lupus erythematosus ... - Sjögren syndrome
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... Glomerulonephritis Myositis ... #erythematosus
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
BEE Syndromes - ... central nervous system ... • Systemic lupus ... erythematosus ... ANCA-associated vasculitides
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
ANCA-positive vasculitis ... ANCA-negative vasculitis ... Immune Complex: Systemic ... lupus erythematosus ... Rheumatoid arthritis, Systemic
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ischemia - Skin: erythematous ... Conjunctivitis, mucositis ... : • Behçet Syndrome ... • Cogan Syndrome ... lupus erythematosus
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... central nervous system ... Peripheral Nervous System ... Paraneoplastic syndrome ... dystrophies Work
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... positive NMO only): Myositis ... autoimmune disorders (Systemic ... lupus erythematosus ... , Sjögren syndrome
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... Neuropsychiatric systemic ... • Transverse Myelitis