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diagnosis clinical management differential nephrology pharmacology algorithm pocus cardiology pathophysiology causes ultrasound treatment radiology hyponatremia obgyn table classification criticalcare comparison
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
N-Acetyl Cysteine (NAC ... NAC helps replenish ... Figure 2.1 NAC has ... GSH) precursor, NAC3 ... substitute, and NAC4
#paracetamol #paracetamoloverdose #NAC
paracetamoloverdose #NAC
Addictions: Pathogenesis Mesolimbic Dopaminergic Pathway: • Dopaminergic neurons in Ventral Tegmental Area (VTA) in midbrain under continuous
Nucleus Accumbens (NAc ... ) • The NAC receives ... response) • The NAC
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
acetazolamide) Nat-Cl ... symport Na and ... spironolactone) Nat ... +-2CF symport Na ... direct effect) #NaCI
Gram Positive Cocci - Bacteria Identification Algorithm Catalase(+) - Coag(+): Staphylococcus aureus - Coag(-)
Hemolysis - 6.5% NaCl ... - 6.5% NaCl
Adverse Effects of NSAIDs Prostaglandins decreased - Gastric mucosal damage with ulcer formation, bleeding, and perforation -
decreased excretion of NaCl
Single Syringe Adenosine - Instructions 1) Dilute 6-12 mg of adenosine in a syringe for a total
mL - Use 0.9% NaCl ... to place IV in AC
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
cotransporter (NCC ... distal tubule. ↑ Nacl
N-Acetylcysteine (NAC) restores hepatic glutathione! Found to have 21-28% reduction in mortality for acetaminophen-induced hepatic failure The earlier
N-Acetylcysteine (NAC
Management of SIADH Treat underlying cause: • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Start with 1g NaCl ... • With lower Na
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