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diagnosis betadglucan galactomannan infectiousdiseases treatment antibiotic aspergillus bcnie biomarkers bloodculture candidemia candidiasis comparison eosinophilia eosinophils failure falsepositives fungemia gravis guidelines
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup and Management ... or TEE unless clinical ... concern for endocarditis ... #candida #candidiasis ... #treatment #fungal
Hematuria in Post-Renal Transplant Patient Prevalence up to 12% in the postrenal transplant patient • Bacterial: Escherichia
Simple Virus • Fungal ... : Candida, Cryptococcus ... (Goodpasture's syndrome ... diagnosis #kidney #blood ... #urine #management
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... antimicrobials, clinical ... (Aspergillus, Candida ... antiphospholipid syndrome ... #diagnosis #differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
• Pathogens: Candida ... cut-offs defined in clinical ... albumin, or other blood ... BAL GM does not differentiate ... GM) - IVIg, blood
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
NMS, serotonin syndrome ... bacteria: Viral, Fungal ... lines, osteo, endocarditis ... CNS, prostate, ocular ... thrombophlebitis), HAP, Blood
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Routine use: Candida ... cut-offs defined in clinical ... >90% (In most clinical ... in BAL does not differentiate ... GVHD), Certain blood
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Clinical Picture ... Ocular- 50%: Ptosis ... life-threatening Differential ... Bedside: ice pack ... Gravis #diagnosis #management
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... than 1500 and clinical ... eosinophilia with blood ... Infection: helminthic, fungal ... diagnosis #hematology #differential
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... skin lesions, ocular ... Parvovirus B19 • Candida ... #Differential # ... Diagnosis #Management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Major blood ... stain of clinical ... osteoarticular, pulmonary, ocular ... arthritis, and endocarditis ... #Diagnosis #Management
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