18 results
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
These cells can ... go on to block blood ... exclusively affects black ... The underlying pathophysiology ... #Features #Signs
Scarf Sign (Normal) on Physical Exam

The scarf sign is used to assess developmental age and muscle
Scarf Sign (Normal ... Exam The scarf sign ... the elbow will cross ... midline; in a term ... #Scarf #Sign #PhysicalExam
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Diagnostic Algorithm Pathophysiology ... : - Catch-all term ... range of potential pathophysiologic ... - Pathophysiology ... Ill-appearing, vital sign
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
-> GAS antigen cross-reacts ... B and CD-4+ T cells ... RheumaticFever #pathophysiology ... #diagnosis #signs
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
remainder likely arises ... Signs of immunodeficiency ... from precursor cells ... humoral immunity Signs ... Agammaglobulinemia #XLinked #pathophysiology
Clinical Manifestations of Sickle Cell Disease

Anaemia
Infection
Painful crises
Priapism
Splenomegaly
Long Term Problems - Short stature and delayed puberty, Stroke
Infection Painful crises ... Splenomegaly Long Term ... SickleCell #Disease #Signs
Skin Mottling - Skin mottling, a common clinical sign in patients in shock, is a violaceous
common clinical sign ... B) #Clinical #Derm ... Hypoperfusion #Shock #NEJM
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
various inflammatory cells ... histopathologic term ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
small joints (wrists ... • Plasma cells ... Extra-articular signs ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
disease (sickle crisis ... hematopoietic marrow cells ... hypolucency "Crescent sign ... AvascularNecrosis #pathophysiology ... #diagnosis #signs