7 results
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
B and CD-4+ T cells ... Prolonged PR Interval, Carditis ... pathophysiology #diagnosis #signs ... #symptoms #complications
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... various inflammatory cells ... histopathologic term ... #HSP #IgA #Vasculitis ... Pathophysiology #Diagnosis #Signs
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
• Langerhan cells ... removal of these cells ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs ... #symptoms #complications
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... or basket cells ... kinase (BTK) Complications ... leukemia • GI complications ... Contamination, colitis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... When to Consider Vasculitis ... purpura: Strong sign ... Multinucleated giant cells ... pulmonary infiltrates/cavities
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... and ophthalmic complications ... systemic sx + signs ... differential diagnosis = vasculitis ... GCA #Temporal #Signs
Pyoderma Gangrenosum in Ulcerative Colitis- ...left chest (Panel A) and leg (Panel B). The physical examination
in Ulcerative Colitis ... leukocytoclastic vasculitis ... #clinical #photo ... #NEJM #pyoderma ... #derm