8 results
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
expression - Age: GCA ... yrs old; F>M Signs ... Anemia - Giant cells ... Pathophysiology #Diagnosis #Signs ... #Symptoms #Vasculitis
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
arteritis (GCA) ... systemic inflammatory vasculitis ... systemic sx + signs ... them, but urgent rheumatology ... #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... Elevated ESR and CRP GCA ... develop in pts with GCA ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
histopathologic term ... Arthralgia's (common), arthritis ... and ankles) #HSP ... Pathophysiology #Diagnosis #Signs ... #Symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
and often causes arthritis ... and branches • GCA ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... (rare), Arthritis ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... meningitis), MCC CNS symptoms ... disease, ulcerative colitis ... diagnosis #management #signs ... #symptoms #rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Agent Orange or Hep ... with no early symptoms ... Physical Exam/Signs ... Contamination, colitis ... workup #oncology #hematology