7 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... • PNH
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... - Idiopathic monoclonal ... Diagnosis: • hemolytic ... - Mycoplasma, EBV ... Hemoglobinuria (PCH
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Hemolysis in Hereditary ... structure of a normal ... destruction or hemolysis ... Pathophysiology #Honc ... HereditarySpherocytosis #NEJM
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH ... Liver Disease, PNH ... Blood Smear ↑ abnormal ... Urobilinogen #Hemolysis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... - If both are normal ... Gilbert's syndrome • Hemolysis ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... Cryoglobulinemic, Hypo/normo-complementemic ... WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
it represents a monoclonal ... Causes of Monoclonal ... endocrinopathy, monoclonal ... acute HIV, HBV, EBV ... light chain • Normal