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diagnosis hematology hemolysis agglutinin algorithm anemia causes disease extravascular falsepositives fungal galactomannan hemolytic intravascular laboratory myopathy myositis sensitivity testing
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... : Warm AIHA, Cold ... Drug-associated, PCH ... Liver Disease, PNH ... Laboratory Tests
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... Warm AIHA • Cold ... AIHA • Alloimmune ... AIHA • PCH ... • PNH
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... - Mycoplasma, EBV ... younger pts) Differential ... • Diagnostic Test ... Donath-Landsteiner test
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Other +s: PCP, Histo ... IA PPV NPV ... the use of this test ... in BAL does not differentiate ... blood products #BetaDGlucan
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Diagnostic Tests ... RP-ILD), dermato-rheumatologic ... • ANA < 20 % IBM ... #differential #
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