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diagnosis hematology algorithm hemolytic causes extravascular intravascular agglutinin aiha disease hepatitis hepatology injury liver monoclonal oncology paraproteinemias testing workup
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... AIHA • Alloimmune ... AIHA • PCH ... • PNH ... anemia •
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... hemoglobinuria (PNH ... (AIHA)"Cold" (usually ... (e.g. primary cold ... Extravascular #Causes #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... anemia • Cold ... - Mycoplasma, EBV ... younger pts) Differential ... • Diagnostic Test
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... : Warm AIHA, Cold ... Defects: Sickle cell anemia ... Laboratory Tests
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... alpha-methyldopa COLD ... #Hemolytic #Anemia ... AIHA #Diagnosis #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... elliptocytosis, autoimmune ... #Anemia #Differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... HBV, HCV, HEV, EBV ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... extrahepatic source - Tests
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic ... anemia due to cold ... Hematology #Monoclonal #Differential
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